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Spectroscopic Study of Haemoglobin Ligand Forms and Erythrocyte
Membrane Dynamics at Alcohol Intoxication of White Rats
1,2Dudok K.P., 1,3Moroz O.M., 1Dudok
T., 1,3Vlokh I., 1Vlokh R.
1Institute of Physical Optics, 23 Dragomanov
Str., 79005 Lviv , Ukraine
2Biochemical Department, Lviv National University,
4 Hrushevsky Str., 79005 Lviv, Ukraine
3Scientific Research Laboratory, Lviv State
Medical University, 69 Pekarska Str., 79010 Lviv, Ukraine
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The results of spectroscopic studies are presented for desoxy-, oxy-,
carboxy-, sulf- and methhaemoglobins of white rats and their posterity
under the conditions of a durable (1 to 6 months) alcohol intoxication.
The changes in the dynamics of oxy- and methhaemoglobin are found for the
animals having consumed 15%-ethanol during 1-4 months. It is also found
that structural and functional properties of erythrocyte membranes have
changed for the white rats that consumed ethanol during 4-6 months. The
increased sensitivity of erythrocytes to the action of haemolytic agents
is detected for the posterity of alcoholized parents. The obtained results
show that alcohol intoxication influences not only the structural and functional
properties of periphery blood erythrocytes but also the nemogenous system.
PACS: 42.66.-p, 33.55.-b
Key words: spectroscopy, haemoglobin, ligand forms, erythrocytes,
alcoholism
doi 10.3116/16091833/5/1/32/2004 |
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References
1. Guluy MF, 2000. Ukr. Biochem. J. 72: 103.
2. Bozhko GKh, Strelyanaya O.I., Voloshin PV., 1998. Ukr. Biochem.
J. 70: 120.
3. Babich LG, Shlykov SG, Borisova LA, 2002. Ukr. Biochem. J. 74: 19.
4. Gette IF, Kaminskaya LA, Danilova IG, 1998. Proc. of 5th Internat.
Meet. "Bioantioxydant", Moscow, 109 .
5. Hazelett SE, Liebelt RA, Brown WJ, Androulakakis V, Jarijoura D,
Truitt EB, 1998. Alcoholism: Clinical & Exper. Research. 22(8): 1813.
6. Tareshita T, Morimoto K, 2000. Alcoholism: Clinical & Experim.
Research. 24(1): 1.
7. Mishchuk DO, Kapla AA, 2003. Ukr. Biochem. J. 75: 55.
8. Bilyi OI, Dudok KP, Veliky MM, 2000. Pros. SPIE 4515: 199.
9. Terskov IA, Hitelzon II, 1954. Biophysics 11: 259.
10. Burmistrov S?, Borodkin YuS, 1990. Pharmacology and Toxicology
53: 59.
11. Maximovich Ya, Kresyun VI, Aryaev VL, 1983. Ukr. Biochem. J. 55:
643.
12. Kharchenko NK, Sinitsky VN, 1993. Ukr. Biochem. J. 65: 53.
13. Konoplitskaya KL, Mnyshenko TI, Zakrashun TE, 1993. Ukr. Biochem.
J. 65: 33. |